Product ID:4273, BUPIVACAINE HYDROCHLORIDE INJ., U.S.P.
MSDS Date:12/13/1991
FSC:6505
NIIN:00-179-0037
MSDS Number: BWMPM

ABBOTT LABORATORIES,HOSPITAL PRODUCTS DIV

ABBOTT PK DEPT 361 AP 6B
NORTH CHICAGO, IL 60064-3502
US

Emergency Phone: 312-937-7901

Info Phone: 312-937-7901

Cage: 60060

ABBOTT LABORATORIES INC

NORTH CHICAGO, IL 60064 US

Telephone: 847-935-7177

Cage: 60060

WATER

CAS: 7732-18-5

RTECS: ZC0110000

Fraction By Weight: UNKNOW

BUPIVACAINE HYDROCHLORIDE

CAS: 14252-80-3

RTECS: TK1250000

Fraction By Weight: UNKNOW

LD50 LC50 Mixture:LD50(ORAL RAT)=18 MG/KG (PURE DRUG)
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:CONTAINS DRUG IN AQUEOUS SOLUTION.
HEALTH DATA FOR THIS PRODUCT BASED UPON BUPIVACAINE HCL CONTENT.
LOCAL ANESTHETIC THAT PRODUCES ANESTHESIA BY BLOCKAGE OF NERVE
CONDITION & CAN ALSO ADVERSLEY AFFECT THE CNS & HEART. PRODUCED
FETAL MORTALITY IN ANIMALS AT 5-9 TIMES MAXIMUM RECOMMENDED DOSE.
MAY DO SO IN HUMANS.
Explanation of Carcinogenicity:MANUFACTURER GAVE NO COMMENTS OTHER THAN
THE ABOVE REFERENCES TO THE THREE LISTINGS.
Effects of Overexposure:NONE FROM INTACT VIALS. IN CLINICAL USE EFFECTS
INCLUDE NUMBNESS, EXDITATION/DEPRESSION, RESTLESSNESS, ANXIETY,
DIZZINESS, TINNITUS, BLURRED VISION, TREMORS, CONVULSIONS,
HYPOTENSION, BRADYCARDIA, VEN TRICULAR ARRHYTHMIAS, HEART BLOCK, &
CARDIAC ARREST.
Medical Cond Aggravated by Exposure:NONE FROM INTACT VIALS. DATA
SUGGEST PRE-EXISTING CNS OR CARDIOVASCULAR AILMENTS.
HYPOSENSITIVITY TO AMIDE TYPE LOCAL ANESTHETICS.

First Aid:REMOVE FROM SOURCE OF EXPOSURE. IF SKIN OR EYE CONTACT OCCURS
FLUSH W/COPIOUS AMOUNTS OF WATER. IF IRRITATION PERSISTS OR SIGNS
OF TOXICITY OCCUR, SEEK MEDICAL ATTENTION. NO KNOWN ANTIDOTE.
PROVIDE S YMPTOMATIC/SUPPORTIVE CARE, MAINTAININGVENTILATION,
CONTROLLING CONVULSIONS, & MONITORING CARDIOVASCULAR FUNCTION, AS
NECESSARY.

Flash Point:NON-FLAMMABLE
Fire Fighting Procedures:NONE
Unusual Fire/Explosion Hazard:NONE

Spill Release Procedures:CLEAN UP PROMPTLY. AVOID SKIN/EYE CONTACT.
Neutralizing Agent:MFR GAVE NO INFORMATION ON MSDS.

Handling and Storage Precautions:NONE
Other Precautions:NONE

Respiratory Protection:NONE SHOULD BE NEEDED
Ventilation:NO SPECIAL PROVISIONS REQUIRED.
Protective Gloves:NONE SHOULD BE NEEDED
Eye Protection:NONE SHOULD BE NEEDED
Work Hygienic Practices:MFR: ? HMIS:USE STRICT CHEMICAL HYGIENE
PRACTICE. AVOID UNNECESSARY EXPOSURE. WASH THOROUGHLY BEFORE EATING
OR DRINKING.
Supplemental Safety and Health
NONE

HCC:N1
NRC/State Lic Num:NONE
Boiling Pt:B.P. Text:WATER
Melt/Freeze Pt:M.P/F.P Text:WATER
Spec Gravity:WATER
pH:4-6.5
Solubility in Water:AQUEOUS SOLUTION
Appearance and Odor:CLEAR LIQUID
Percent Volatiles by Volume:NEG.

Stability Indicator/Materials to Avoid:YES
NONE
Stability Condition to Avoid:NONE
Hazardous Decomposition Products:NONE
Conditions to Avoid Polymerization:WILL NOT OCCUR.

Waste Disposal Methods:NO SPECIAL REQUIREMENTS.

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This information is formulated for use by elements of the Department
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expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.